کنگره بین المللی زیست فناوری گیاهان دارویی و قارچ های کوهی

صفحه اصلی / چهارمین کنگره بین المللی و پنجمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی

Neuroprotective Effect of Naringin and Naringenin against Parkinson's disease: Mechanism of Action

نویسندگان :

Reyhaneh Tamimi¹ Haniyeh Motie Arani² Saeed Hesami Tackallou³ Soheila Zamanlui Benisi⁴ Zahra Shahi⁵ Sara Sharifi Ghombavani⁶

1- دانشگاه آزاد اسلامی واحد تهران مرکزی 2- دانشگاه آزاد اسلامی واحد پزشکی تهران 3- دانشگاه آزاد اسلامی واحد تهران مرکزی 4- دانشگاه آزاد اسلامی واحد تهران مرکزی 5- دانشگاه آزاد اسلامی واحد تهران مرکزی 6- دانشگاه آزاد اسلامی واحد تهران مرکزی

کلمات کلیدی :

Flavonoids،Naringenin،Naringin،Neurodegeneration،Neuroprotection،Parkinson's disease

چکیده :

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects at least 1% of the population over the age of 60 and is characterized by slow and progressive loss of dopaminergic neurons in the substantia nigra. Aggregation and deposition of α-synuclein, neuroinflammation, excitotoxicity, oxidative stress، genetic mutations, and many other factors may contribute to PD-related neurodegeneration. Naringin and naringenin are two beneficial natural compounds belonging to citrus flavonoids that possess numerous biological and pharmacological properties, including strong anti-tumor, antiviral, antibacterial, anti-inflammatory, antioxidant, cardioprotective, and neuroprotective activities. Recent studies have shown that they provide neuroprotection against several neurodegenerative diseases, including PD. This review aims to explore these compounds' therapeutic and neuroprotective mechanisms in neurodegenerative disorders in the context of gene expression and signaling pathways, particularly in Parkinson's disease. Methods: In this systematic review, we searched PubMed/Medline, Science Direct, Scopus, Google Scholar, and the Web of Science databases up until May 2022 and identified 125 papers for the search terms naringin, naringenin, neurodegeneration, neuroprotection, Parkinson’s disease, and gene expression and signaling pathways. Among full-text articles assessed, only original articles that met eligibility criteria and investigated molecular mechanisms involved in the neuroprotection effects of these compounds were selected for further analysis. Results: The evidence reviewed in the present study indicates that naringin and naringenin protect nigrostriatal dopaminergic neurons against neurodegeneration and oxidative damage through regulation of genes involved in apoptotic pathway(through the downregulation of Bax and overexpressed Bcl-2, inhibition of the phosphorylation of c-Jun N terminal kinase (JNK)/p38 and abrogating caspase 3) , neuroprotective effects (by the induction of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) , glial cell line-derived neurotrophic factor (GDNF), and vascular endothelial growth factor), increasing the level of dopamine and its metabolites, overexpression of protective proteins (including parkin, PARK 7 protein (DJ1), tyrosine hydroxylase (TH) and C terminus Hsp70 interacting protein (CHIP)), decreasing the pro-inflammatory cytokines (TNFα and IL1β) and reducing neuroinflammation by decreasing the level of TNF-α and nuclear factor-κB (NF-κB) as well as suppression of microglial activation and the subsequent pro-inflammatory factors release. Conclusion: The results of the present study concluded that naringin and naringenin can effectively exert neuroprotective effects in PD models. However, the need to develop novel drug delivery systems and further clinical trials have been discussed Keywords: Flavonoids, Naringenin, Naringin, Neurodegeneration, Neuroprotection, Parkinson's disease