کنگره بین المللی زیست فناوری گیاهان دارویی و قارچ های کوهی

صفحه اصلی / سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی

بررسی تاثیر تیمول روی سطح سرمی آنتی اکسیدان تام (TAC) و فاکتور نکروز تومور (TNF-α) در موشهای نر چاق نژاد NMRI

نویسندگان :

فاطمه جلالوند¹

1- دانشگاه آزاد اسلامی واحد ملارد

کلمات کلیدی :

Thymol, Total Antioxidant, Factor Tumor Necrosis, Obese Mice

چکیده :

Obesity is the result of an unhealthy diet, a lack of antioxidants and unsaturated fats. Oxidative stress has a role in the onset of chronic diseases associated with obesity. Thymol is one of the phenolic compounds of thyme which is widely used as a general antiseptic in surgery, agriculture, cosmetics and nutrition industries. In a recent study, the effect of thymol on serum levels of total antioxidant (TAC) and tumor necrosis factor (TNF-α) in obese mice was investigated. The control and experimental groups were fed a standard and high-calorie diet for 8 weeks, respectively. The experimental group was gavaged with thymol (12 mg / kg / day) for 8 weeks. The end of treatment, blood samples, to investigate serum TAC and TNF-α was performed. Treatment of obese mice with thymol resulted in a significant increase in serum TAC levels and also a significant decrease in serum TNF-α levels compared to control mice. Because oxidative stress plays a pivotal role in the onset of chronic obesity-related diseases, thymol can be used to treat obesity and increase antioxidant levels.