کنگره بین المللی زیست فناوری گیاهان دارویی و قارچ های کوهی

صفحه اصلی / سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی

Effects of Sulforaphane in the Autistic Symptoms in Rat with by Prenatal Valproic acid induction

نویسندگان :

Sahar Heydari¹ Ali Mahmoudi²

1- دانشگاه علوم پزشکی سبزوار 2- دانشگاه علوم پزشکی مشهد

کلمات کلیدی :

Autism, Behavior test, sulforaphane, VPA

چکیده :

Introduction: Autism spectrum disorder (ASD) is a wide range of disorders in the nervous system. Several prominent features are commonly observed in autistic patients; impairments in social communication, repetitive behaviors, and anxiety. Various research verified the responsibility of VPA-induced autism-like behavior. Sulforaphane, which has been reported, had positive effects on ASD. Methods: Pregnant rats were injected intraperitoneally on embryonic day 12.5 with 500 mg/kg valproic acid to inducing an autistic rat model. Administration of male offspring using sulforaphane that injected intraperitoneally with a single dose of 12.5 mg/kg daily for 20 days. Sniffing for Social interaction, Y-maze for repetitive behavior, and elevated plus maze for anxiety was measured after the treatment period. Results: One-way ANOVA observed a significant effect in rats that were prenatally exposed to VPA compared to control in the sniffing duration (P < 0.05), spontaneous alternation, and anxiety (P < 0.0001) significantly were changed. However, after receiving treatment with sulforaphane, the result indicated that impairment in social (p < 0.0001) and anxiety (p < 0.05) significantly improved. Spontaneous alternation as an indicator of repetitive behaviors also increased but was not significant. Conclusion: It seems that sulforaphane could recover VPA-induced imperfection in social interaction, anxiety, and repetitive behaviors.