کنگره بین المللی زیست فناوری گیاهان دارویی و قارچ های کوهی

صفحه اصلی / سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی

Evaluation of the protective effect of green tea polyphenols for sub-acute toxicity of diazinon in mice

نویسندگان :

Fereshteh Mehri¹ Amir Sasan Mozaffari Nejad²

1- دانشگاه علوم پزشکی همدان 2- دانشگاه علوم پزشکی همدان

کلمات کلیدی :

Diazinon, Green tea polyphenols (GTP), Oxidative stress, Mice

چکیده :

Background: Studies have shown that an organophosphorus pesticide such as diazinon induces oxidative stress injury and damage in various tissues. Objectives: This study conducted to investigate the effects of green tea polyphenols (GTP) on the liver function of diazinon -poisoned animals. Methods: Twenty-eight mice were divided into four groups of the control, GTP (400 mg/kg), diazinon + GTP, and diazinon. Animals received malathion 80 mg/kg and SA 400 mg/kg for one week through intraperitoneal injection. Then, their liver and blood samples were extracted, and alanine aminotransferase, aspartate aminotransferase concentrations in serum as well as biomarkers of oxidative stress such as Total Antioxidant Capacity (TAC), Lipid Peroxidation (LPO), and catalase (CAT) activity in the liver tissue were measured. Results: The results indicated that the GTP administration decreased the level of liver LPO compared with that in the diazinon group. Also, receiving GTP increased liver TAC and CAT levels in mice, which this difference was significant than the diazinon group. In addition, the GTP group showed a significant reduction in liver enzyme levels, then the diazinon-treated group. Conclusion: Based on the results, GTP exerted protective effects against diazinon poisoning, by the decrease of oxidative stress. Thus, GTP can be an antioxidant to counteract the risk effects of diazinon poising in liver tissue.