کنگره بین المللی زیست فناوری گیاهان دارویی و قارچ های کوهی

صفحه اصلی / سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی

Effects of different con concentrations of Ziziphus Jujube L. (Rosales: Ramnaceae) on Inhibition of breast cancer cell proliferation (MCF-7)

نویسندگان :

Leila Soltani¹ Maryam Darbemamieh²

1- دانشگاه رازی 2- دانشگاه رازی

کلمات کلیدی :

Aqueous extract, Anti-cancer, Cytotoxicity, Jujube, Apoptosis

چکیده :

Ziziphus Jujube L. (Rosales: Ramnaceae) is a fruit tree that grows with different characteristics and flavors in some tropical and subtropical regions of the world. This fruit has been used as food and medicine. Phytochemical studies on Z. jujube have led to the extraction and identification of various alkaloids, flavonoids, tannins, sterols and saponin. The aim of this study was to evaluate the anti-proliferative properties of Z. Jujube aqueous extract in low concentrations on breast cancer cells (Mcf-7). After preparation of Z. Jujube fruit, its kernels were separated and the fruit was dried. The concentrations of 30, 60, 120 and 240 μg/ml from this extract were added to the cell culture medium. The non-treated group was considered as a control. Anti-proliferative properties were evaluated by MTT assay. Data were analyzed in SPSS software and a significance level of 5% was considered. Addition of 240 μg/ml aqueous extract to the culture medium of cancer cells had the greatest toxicity effect compared to other concentrations of aqueous extract (p<0.05). In this study, the anti-proliferative effects of different concentrations were dose-dependent. Finally, it seems that Z. Jujube aqueous extract has relative anti-proliferative effects at high concentrations, which used in this essay.