کنگره بین المللی زیست فناوری گیاهان دارویی و قارچ های کوهی

صفحه اصلی / سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی

Protective effect of Vitex agnus‑castus on memory deficits induced by repeated exposure toluene in mice

نویسندگان :

Soroush Farhadi Pahndari¹ Akbar Hajizadeh Moghaddam² Fereshteh Mirmohammadrezaei³

1- دانشگاه مازندران 2- دانشگاه مازندران 3- دانشگاه مازندران

کلمات کلیدی :

Toluene, Vitex agnus‑castus, mice, memory defects

چکیده :

Protective effect of Vitex agnus‑castus on memory deficits induced by repeated exposure toluene in mice Soroush Farhadi Pahndari1, Akbar Hajizadeh Moghaddam1, Fereshteh mirmohammadrezaei1 1.Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran Introduction: Toluene is an organic solvent widely used in many industrial processes. long-term toluene abuse has been associated with cognitive impairment, memory deficits, difficulty to concentrate and decreased IQ. toluene induces an oxidative imbalance in the hippocampus and prefrontal cortex. Vitex agnus‑castus is a source of phytoestrogens, flavonoids and apigenins. Phytoestrogens from V. agnus-castus affected on anxiety behaviors. The aim of this study was to determine the effect of V. agnus-castus on Toluene-induced behavior disorders in mice. Method & material: In this experimental study, 50 mice were collected and divided into 5 groups: control, sham, extract, toluene, and toluene with the extract. Then we injected toluene and the extract intraperitoneally to the mice for 14 days. At the end, the mice were tested for Novel object test. Result: The Discrimination index of toluene group had a significant decrease compared to the control group (p<0.01) and the Discrimination index in toluene with extract group had a significant increase compared to the toluene group (p<0.001). Discussion: Regular treatment with Vitex agnus‑castus for two weeks remarkably improved memory defects. Therefore, can be expressed that V. agnus-castus neuroprotective action for treatment can be useful in medicine. Keyword: Toluene, Vitex agnus‑castus, mice, memory defects.