کنگره بین المللی زیست فناوری گیاهان دارویی و قارچ های کوهی

صفحه اصلی / سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی

In vitro anticancer activity of methanolic extract of Chroococcus sp., from Kani Barazan International Wetland

نویسندگان :

Hamieh Goshtasbi¹ Mostafa Akbarzadeh-khiavi² Azam Safary³ Ali Movafeghi⁴ Yadollah Omid⁵

1- دانشگاه تبریز 2- دانشگاه علوم پژشکی تبریز 3- دانشگاه علوم پژشکی تبریز 4- دانشگاه تبریز 5- Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida, USA

کلمات کلیدی :

Anticancer activity, Antioxidant capacity, Apoptosis, Chroococcus turgidusa, Methanolic extract

چکیده :

The current bioprospecting study has been conducted to develop the new anticancer agents with higher efficiency of microalgae isolated from the Kani Barazan International Wetland in the south of Lake Urmia. Microalgae as one of the large and diverse groups of autotrophic organisms are able to use in different biomedical sources due to their antioxidant and anticancer properties. In this study, biological impacts (DPPH radical scavenging, MTT assay, Annexin VP/I, and cell cycle) of methanolic extract (ME) from Chroococcus turgidusa were evaluated against colorectal and gastric cancer cells. Based on our result, the ME can significantly inhibit cell proliferation and induce apoptosis in SW480 and AGS cell lines. Conclusively, the ME of Ch. turgidusa can be presented as a potential preventive/therapeutic agent in gastrointestinal cancers. To the best of our knowledge there is no scientific published data about Ch. turgidusa anticancer effects.