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سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچ های کوهی
Anti-proliferative and apoptotic effects of Piper cubeba hydroalcoholic extract on the MCF-7 human breast cancer cell line
نویسندگان :
Tayebeh Mohammadi
1
Mehrdad Pooyanmehr
2
Farhang Tafaroji
3
1- دانشگاه رازی
2- دانشگاه رازی
3- دانشگاه رازی
کلمات کلیدی :
Piper cubeba, Breast cancer, MTT, viability.
چکیده :
Breast cancer is the most prevalent cancer and a death leading cause among women worldwide. Based on various former studies, herbs may play a significant role in cancer alternative therapy. This study aimed to evaluate the anti- proliferative and apoptosis inducing potential of Piper cubeba. Its anti-proliferative activity on the human breast cancer cell line (MCF-7) was measured by MTT assay and acridin orange-ethidiuum bromide(AO/ED) staining was used to examine its apoptotic effects phenotypically. The hydroalcoholic extract of Piper cubeba showed anti- proliferative effects in a dose and time dependent manner(P<0.05). IC50 was 1 mg/ul. The anti proliferative activity was associated with an increase of apoptosis as demonstrated by AO/ED staining. Our findings showed anti proliferative and apoptotic effect of Piper cubeba fruit on human breast cancer cell line.
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ثمین همایش، سامانه مدیریت همایش ها و جشنواره ها - نگارش 44.9.10